Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0078dpd3.2 | Session 2 (1) | BSPED2021

100 years of insulin - is it time for a UK Type 1 diabetes screening strategy?’

Besser Rachel

2021 is an important year for diabetes. It is 100 years since insulin was discovered and the first child had their life saved by insulin, turning a death sentence into a chronic condition. Since then, insulin has remained the mainstay of treatment for type 1 diabetes. Outcomes have improved with advances in technology, but outcomes remain suboptimal and, in the UK, around 25% children still present late, in a state of life-threatening diabetic ketoacidosis (DKA). DKA rates hav...
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ea0066d1.1 | (1) | BSPED2019

Besser Rachel

Dr Rachel Besser BSc MBBS (Hons) MRCPCH PhD, is a consultant in paediatric endocrinology at Oxford Children’s Hospital, and Honorary senior clinical lecturer at the University of Oxford, working with both the NIHR Oxford Biomedical Research Centre and the Wellcome Centre for Human Genetics. She came to Oxford in 2016 and was Clinical Lead between 2016–2018, and is now Research and Audit lead for the department. Rachel splits her job between clinical diabetes and diab...
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ea0095ds1.1 | Diabetes Symposium 1 | BSPED2023

Preparing for a softer landing at diagnosis - how to manage a child with pre-T1D

Besser Rachel

Type 1 diabetes (T1D) can be identified pre-symptomatically, by measuring islet associated autoantibodies (IAb). In an analysis from multiple prospective cohort studies, >80% children with two or more IAbs developed clinical T1D over 15 years of follow up. The reasons for identifying children presymptomatically include reducing the risk of diabetic ketoacidosis at diagnosis and the related morbidity and mortality, reducing the need for hospitalisation, providing time to al...
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ea0036cme6 | CME Session | BSPED2014

Trainees update

Besser Rachel , Steele Caroline

The trainee reps (Drs C Steele and R Besser) will provide an update on their activities on behalf of the trainees in the past year including:i) Update of the trainees’ section of the BSPED website.ii) Results of a recent survey of GRID trainees aimed to track training and for future workforce planning.iii) Ongoing activities (such as trainees’ section of the BSPED newsletter) and number of e-mail co...
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ea0066p26 | Diabetes 2 | BSPED2019

Two cases of bilateral cataracts in early type 1 diabetes

Lelliott Alice , Basu Supriyo , Besser Rachel

Introduction: Cataract development as a complication of diabetes is usually associated with increased age and longer duration of diabetes. However, rapidly progressive cataracts have also been described at, or soon after, diagnosis of type 1 diabetes (T1DM). We report two cases of adolescents with T1DM and bilateral cataracts, including one case in which visual loss was the presenting symptom.Cases: A 16-year old non-obese, caucasian boy presented to his...
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ea0051p086 | Diabetes | BSPED2017

Short-term use of the flash glucose monitoring system increases insulin bolusing and self-confidence in paediatric Type 1 diabetes

Yardley Diana , Basu Supriyo , Besser Rachel Elizabeth Jane

Introduction: The Flash glucose monitoring system (FGS) has recently received a licence for children and young people aged 4–17 years with Type 1 diabetes (T1D) in the United Kingdom. Although many families attending a single UK diabetes centre reporting utilising FGS even prior to its licence we aimed to assess the patient experience.Methods: Patients and families were invited to undertake a 14 day FGS trial following group introductory sessions. 8...
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ea0039oc6.2 | Oral Communications 6 | BSPED2015

Mutations in BRAF are associated with septo-optic dysplasia and cardiofaciocutaneous syndrome

Gregory Louise , Besser Rachel , Temple Karen , Davies Justin , Dattani Mehul

Background: Mutations in BRAF are a rare cause of cardiofaciocutaneous syndrome (CFC). Recently, BRAF mutations have been reported in papillary craniopharyngiomas, but have not been described in patients with other hypothalamo-pituitary abnormalities. We describe three patients with CFC and septo-optic dysplasia (SOD) associated with heterozygous BRAF mutations.Cases: Patients presented in childhood with clinical features of ge...
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ea0039ep71 | Gonadal, DSD and reproduction | BSPED2015

Standard GnRH analogue doses do not adequately suppress puberty in adolescent patients

Lam Francis , Besser Rachel , Goedhart Claire , Brain Caroline , Butler Gary

Introduction: Adolescents with persistent gender dysphoria (GD) receive GnRH analogues to achieve pubertal arrest. It is unclear whether this is adequate to achieve biochemical suppression of gonadotrophin (LH, FSH) and sex hormone production.Methods: Gonadotrophins, testosterone and oestradiol were measured in GD patients (15–18 years) before and after monthly Gonapeptyl treatment (3.75 mg i.m.). Patients administered other analogues and/or cross-s...
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ea0036P5 | (1) | BSPED2014

Cerebral oedema: a rare presentation of Addison's disease

Besser Rachel E J , Amores Irene , Inwald David , Dattani Mehul T

Introduction: Cerebral oedema has rarely been reported in adrenal insufficiency. We report a case of decompensated cerebral oedema due to autoimmune adrenalitis.Case report: A 12-year-old boy presented to hospital with a 1 day history of headache, fever up to 39.9 °C, confusion, diarrhoea, and vomiting. He had a left-sided ptosis, reduced conscious level (Glasgow coma scale 8/15) and was hypertensive (blood pressure 134/90 mmHg). He required intubat...
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ea0034p145 | Clinical practice/governance and case reports | SFEBES2014

Training needs in adolescent health and transition in paediatric and adult trainees in diabetes and endocrinology in the UK

Gleeson Helena , Wright Rohana , Besser Rachel , Cheer Kelly , Dimitri Paul , Chapman Simon , on behalf of AYASIG

Background: Training is adolescent health and transition is lacking in medical education. Clinicians working in diabetes and endocrinology across paediatric and adult services need to have the skills to work effectively with this age group. Our aim was to identify the current state of training and to ascertain training needs in trainees.Methods: A questionnaire was developed based on existing questionnaires. Using trainee representatives all paediatric a...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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